Pulsed high intensity focused ultrasound (pHIFU) enhances delivery of doxorubicin in a preclinical model of pancreatic cancer
نویسندگان
چکیده
Pulsed high intensity focused ultrasound (pHIFU) enhances delivery of doxorubicin in a preclinical model of pancreatic cancer Tong Li, Yak-Nam Wang, Tatiana D. Khokhlova, Samantha D’Andrea, Frank Starr, Hong Chen, Jeannine S. McCune, Linda J. Risler, Afshin Mashadi-Hossein, Joo Ha Hwang 1 Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 2 Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA 3 Departments of Pharmacy and Pharmaceutics, University of Washington, Seattle, WA 4 Department of Biostatistics, University of Washington, Seattle, WA
منابع مشابه
Pulsed High-Intensity Focused Ultrasound Enhances Delivery of Doxorubicin in a Preclinical Model of Pancreatic Cancer.
Pancreatic cancer is characterized by extensive stromal desmoplasia, which decreases blood perfusion and impedes chemotherapy delivery. Breaking the stromal barrier could both increase perfusion and permeabilize the tumor, enhancing chemotherapy penetration. Mechanical disruption of the stroma can be achieved using ultrasound-induced bubble activity-cavitation. Cavitation is also known to resul...
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